Inflammation, HIF-1, and the Epigenetics That Follows
نویسندگان
چکیده
منابع مشابه
Inflammation, HIF-1, and the Epigenetics That Follows
We summarize recent findings linking inflammatory hypoxia to chromatin modifications, in particular to repressive histone signatures. We focus on the role of Hypoxia-Induced Factor-1 in promoting the activity of specific histone demethylases thus deeply modifying chromatin configuration. The consequences of these changes are depicted in terms of gene expression and cellular phenotypes. We final...
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Introduction ATP production is required to support physiological function in all cells. Methods of ATP production vary between cell types and cellular activation states. Glucose can be used to fuel ATP production through two linked metabolic pathways: glycolysis and the TCA cycle. In glycolysis, glucose is converted into pyruvate in the cytoplasm and phosphates are transferred to ADP to generat...
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The AMP-activated protein kinase is found in all eukaryotic cells. Once activated, the kinase switches on ATP-producing catabolic pathways and switches off ATP-consuming processes,both via direct phosphorylation of downstream targets, and thus is called a cellular energy regulator . A variety of novel downstream target proteins have been discovered recently, which provide new insight into eluci...
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Human T-lymphotrophic virus type 1 (HTLV-1) is a retrovirus that is thought to infect approximately 10-20 million people worldwide. The majority of infected individuals remain asymptomatic carriers lifelong. HTLV-1 is thought to cause both local and systemic inflammatory diseases. The most common inflammatory condition associated with HTLV-1 is HTLV-1 associated myelopathy/Tropical spastic para...
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ژورنال
عنوان ژورنال: Mediators of Inflammation
سال: 2010
ISSN: 0962-9351,1466-1861
DOI: 10.1155/2010/263914